Alternative REST Splicing Underappreciated
نویسندگان
چکیده
منابع مشابه
Role of Aberrant Alternative Splicing in Cancer
Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
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Huntington's disease (HD) is caused by a genetically mutated huntingtin (mHtt) protein with expanded polyQ stretch, which impairs cytosolic sequestration of the repressor element-1 silencing transcription factor (REST), resulting in excessive nuclear REST and subsequent repression of neuronal genes. We recently demonstrated that REST undergoes extensive, context-dependent alternative splicing, ...
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Alternative splicing events are classified into four main subgroups: (i) exon skipping (cassette exons), where the exon can be spliced out of the transcript together with its flanking introns; (ii) alternative 5�ss and (iii) 3�ss selection, which are the results of the recognition of two or more splice sites at one end of an exon; and (iv) intron retention, in wh...
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In order to comprehend the influence of evolutionary changes in gene structure on the alternative splicing mechanism, we work on three related subjects: (i) conservation of exonintron sequences, (ii) splice site score changes and (iii) length data changes, across the vertebrate tree. We have analyzed conservation levels of human Alternative cassette exons (ACEs) ...
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ژورنال
عنوان ژورنال: eneuro
سال: 2018
ISSN: 2373-2822
DOI: 10.1523/eneuro.0034-18.2018